Systematic Network Creation for Human Insulin Receptor Substrate-1 by Systemic Biology Technique

Metabolic actions of insulin are mediated by the insulin receptor/insulin receptor substrate (IRS)-1/ phosphatidylinositol 3-kinase signaling pathway in insulin target organs including the liver, skeletal muscle and adipose tissue. To understand the actual pathway of IRS-1 is the scientists’ hope for better understanding the disease mechanism. In this work, a systematic network creation for human insulin receptor substrate 1 by systemic biology technique was performed. According to this work, there are at least 9 genes directly related to IRS-1 gene. Of interest, the relation of diabetes to some identified genes can be seen. In addition, identified relation to some genes implies a correlation between IRS-1 and cancer. The systematic network of IRS-1 created in this study could provide useful data for further works in diabetic and oncologic medicine. INTRODUCTION